Johns Hopkins University announced Thursday that it will be forced to lay off more than 2,000 employees due to the Trump administration’s substantial cuts to foreign aid funding.

“This is a difficult day for our entire community. The termination of more than $800 million in USAID funding now compels us to wind down critical work both in Baltimore and internationally,” the university stated.

As a leading research institution based in Baltimore, Maryland—about an hour north of Washington, D.C.—Johns Hopkins is eliminating 1,975 positions across 44 countries, along with 247 jobs in the United States.

The cuts will significantly impact key programs, including the university’s medical school, the Bloomberg School of Public Health, and Jhpiego—a global health nonprofit affiliated with Johns Hopkins for over 50 years that works to improve healthcare in underserved countries.

“Johns Hopkins is immensely proud of the contributions made by our colleagues in Jhpiego, the Bloomberg School of Public Health, and the School of Medicine to support maternal and infant health, combat disease, provide clean drinking water, and advance life-saving initiatives worldwide,” the university stated.

With these layoffs, Johns Hopkins becomes one of the universities most affected by the reduction in federal funding for research.

The university receives approximately $1 billion annually from the National Institutes of Health (NIH) and is currently conducting 600 clinical trials, according to The New York Times. Hopkins is also one of the plaintiffs in a federal lawsuit challenging the funding cuts.

The U.S. Agency for International Development (USAID), which funds global humanitarian and health initiatives in approximately 120 countries, has been the largest financial backer of Jhpiego.

President Donald Trump, who has been working to scale back the agency, signed an executive order in January freezing all U.S. foreign aid to reassess overseas expenditures. Critics argue that such cuts to USAID programs could have devastating consequences for millions of people worldwide.